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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in grown-ups with a body mass index (BMI) greater than 27, provided they also suffer from weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four.1% as opposed to participants who have been given placebos) after a 12- month period, while a separate study involving patients with type 2 diabetes had an average weight loss of 2% over treatment with placebo at twelve months.

    Using two separate drugs to lose weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with fat loss and the those who go through it one should err assisting caution and allow FDA do its job and demand some study be done in order that the public knows the side effects and risks of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say everything to keep people on their medications.

    Researchers found that participants using this drug for the year, dropped a few pounds within 4 weeks and have kept the extra weight off during the entire 56 weeks of the study. Contrave is really a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them far better and safer.

    Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular will be the fact that since right now there are not any long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure and heart rate, and really should not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high hypertension, and also by you are not heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients for the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

    New UCLA study on smokers with mental, drug, and alcohol problems